Positive regulation of pseudopodium assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of pseudopodium assembly pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGBP1, ZNF32, and FBXO41, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of pseudopodium assembly activity versus IGBP1 in BONE (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IGBP1 →	-0.627	-0.223	.007	.009	3	5
OESOPHAGUS	ZNF32 →	-1.321	-0.148	<.001	.005	3	4
OVARY	FBXO41 →	-1.032	-0.223	.004	.003	3	4
KIDNEY	CHPT1 →	+1.012	+0.120	.005	.002	3	3
KIDNEY	KLK8 →	+0.154	+0.096	.003	.003	3	3
KIDNEY	PHKG2 →	+0.569	+0.113	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031274 vs IGBP1 — BONE

Explore this scatter interactively →