Biomineral tissue development

Across TCGA patient cohorts, RNA activity of the Biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPP1, COP1, and GCKR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biomineral tissue development activity versus UPP1 in LSCC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UPP1 →	+1.052	+0.264	.001	<.001	3	6
OV	COP1 →	-0.427	-0.594	<.001	.004	3	5
OV	GCKR →	+0.221	+0.440	.003	.007	3	5
BRCA	SERPINE1 →	+1.335	+0.594	<.001	<.001	3	5
LSCC	P4HA2 →	+0.667	+0.276	<.001	<.001	3	5
COAD	ENO2 →	+0.869	+0.841	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031214 vs UPP1 — LSCC

Explore this scatter interactively →