rRNA methylation

Across TCGA patient cohorts, RNA activity of the rRNA methylation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF20_S136, SRRM1_S560, and CTPS2_S568, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA methylation activity versus RNF20_S136 in HNSC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF20_S136 →	+0.285	+0.063	<.001	.002	3	4
LUAD	SRRM1_S560 →	-0.517	-0.023	.002	<.001	3	4
LUAD	CTPS2_S568 →	-0.698	-0.047	.002	<.001	3	4
BRCA	SUPT16H_S650 →	-0.506	-0.019	.008	.006	3	4
BRCA	NUDT12 →	+0.476	+0.021	.003	.001	3	4
LSCC	SPR →	+0.349	+0.037	.002	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031167 vs RNF20_S136 — HNSC

Explore this scatter interactively →