SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FGD3, SASH3, and SPCS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process activity versus FGD3 in HNSC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FGD3 →	-0.280	-0.040	<.001	.005	3	6
LSCC	SASH3 →	-0.423	-0.050	<.001	<.001	3	6
LSCC	SPCS1 →	-0.613	-0.056	<.001	<.001	3	6
GBM	PSME2 →	-0.310	-0.038	<.001	.001	3	6
COAD	CSTA →	-0.832	-0.019	.005	.003	3	5
GBM	GRAP2 →	-0.860	-0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031146 vs FGD3 — HNSC

Explore this scatter interactively →