SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the SCF-dependent proteasomal ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYROXD2, STK32C, and MAGEF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process activity versus PYROXD2 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PYROXD2 →	+1.398	+0.970	.009	.003	2	4
BREAST	STK32C →	+0.941	+0.631	.001	.006	3	3
BLOOD_Leukemia	MAGEF1 →	-1.090	-0.700	.001	.007	3	3
BLOOD_Leukemia	DDX39B →	-0.398	-0.907	.007	.001	3	3
UPPER_AERODIGESTIVE_TRACT	WFIKKN2 →	+0.031	+0.951	.001	.001	3	3
SKIN	MTMR11 →	+0.672	+0.876	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031146 vs PYROXD2 — BREAST

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