Anaphase-promoting complex-dependent catabolic process

Across TCGA patient cohorts, RNA activity of the Anaphase-promoting complex-dependent catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPG, KIF14, and PRR11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anaphase-promoting complex-dependent catabolic process activity versus NCAPG in GBM (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCAPG →	+1.429	+0.750	<.001	<.001	3	7
LUAD	KIF14 →	+0.811	+0.615	.008	.003	3	7
GBM	PRR11 →	+1.045	+0.755	<.001	<.001	3	7
OV	DEPDC1 →	+0.861	+0.751	.005	<.001	3	7
GBM	SPC25 →	+1.059	+0.761	<.001	<.001	3	7
LSCC	CKAP2L →	+0.846	+1.142	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031145 vs NCAPG — GBM

Explore this scatter interactively →