Anaphase-promoting complex-dependent catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Anaphase-promoting complex-dependent catabolic process pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as THCA, show the opposite pattern, with lower activity in tumor tissue.

LUAD, HNSC, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Male	III,IV	+0.091	<.001	11	view →
HNSC	Male	IV	+0.065	<.001	11	view →
COAD	Female	II,III,IV	+0.038	<.001	10	view →
KIRC	All	III,IV	+0.031	<.001	9	view →
LUSC	Male	All	+0.092	<.001	8	view →
LIHC	Male	II,III,IV	+0.080	<.001	8	view →
BLCA	All	All	+0.044	.003	8	view →
KIRP	All	III,IV	+0.044	.004	7	view →
UCEC	All	All	+0.072	<.001	6	view →
BRCA	All	All	+0.036	<.001	6	view →
CHOL	Male	All	+0.123	<.001	5	view →
READ	Male	All	+0.036	.014	5	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0031145–LUAD

Open the LUAD breakdown →