Anaphase-promoting complex-dependent catabolic process

Across TCGA cell cohorts, RNA activity of the Anaphase-promoting complex-dependent catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNA1, NMT2, and SNX15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KATNA1 grouped by Anaphase-promoting complex-dependent catabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KATNA1 →	+0.745	+0.192	.001	.007	3	5
BREAST	NMT2 →	+1.183	+0.166	.002	.003	3	5
OESOPHAGUS	SNX15 →	+0.653	+0.155	<.001	.003	3	5
CNS	ZBED9 →	+0.514	+0.191	.002	.003	3	5
LUNG_SCLC	C19orf12 →	+0.867	+0.164	.004	.004	3	4
KIDNEY	L1CAM →	+2.252	+0.194	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KATNA1 by Anaphase-promoting complex-dependent catabolic process activity — KIDNEY

Explore this box plot interactively →