mRNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC5, PTH1R, and NTM, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-end processing activity versus RFC5 in LSCC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RFC5 →	+0.819	+0.323	<.001	<.001	3	7
OV	PTH1R →	-0.892	-0.237	.001	<.001	3	7
OV	NTM →	-1.041	-0.175	<.001	<.001	3	7
OV	LINC00702 →	-0.414	-0.205	<.001	<.001	3	7
LSCC	DTL →	+0.948	+0.277	<.001	<.001	3	7
GBM	TMEM119 →	-0.952	-0.137	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031124 vs RFC5 — LSCC

Explore this scatter interactively →