RNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDCD11, SCLY, and SAAL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 3'-end processing activity versus PDCD11 in OESOPHAGUS (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PDCD11 →	+0.622	+0.170	.004	.004	3	8
LUNG_NSCLC_LUAD	SCLY →	+0.475	+0.130	<.001	.001	3	7
LIVER	SAAL1 →	+0.737	+0.308	<.001	<.001	3	7
LIVER	ZNF891 →	+0.549	+0.275	.003	.002	3	7
KIDNEY	CAD →	+0.936	+0.218	.007	.001	3	7
URINARY_TRACT	PRR3 →	+1.436	+0.270	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031123 vs PDCD11 — OESOPHAGUS

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