Negative regulation of microtubule polymerization

Across TCGA patient cohorts, RNA activity of the Negative regulation of microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP118, MAP2, and ODC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of microtubule polymerization activity versus RNA5SP118 in GBM (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNA5SP118 →	+1.489	+0.346	<.001	<.001	3	6
GBM	MAP2 →	+1.686	+0.487	<.001	<.001	3	6
HNSC	ODC1 →	+1.313	+0.166	<.001	<.001	3	5
HNSC	SH3BP4 →	+0.634	+0.202	<.001	<.001	3	5
GBM	FXYD6 →	+1.443	+0.390	<.001	<.001	3	5
HNSC	IL17RD →	+0.638	+0.166	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031115 vs RNA5SP118 — GBM

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