Negative regulation of microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SATB1, HUNK, and SCHIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SATB1 grouped by Negative regulation of microtubule polymerization-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SATB1 →	+1.221	+0.840	<.001	.003	3	4
SOFT_TISSUE	HUNK →	+2.151	+1.288	.004	.005	3	4
LARGE_INTESTINE	SCHIP1 →	+0.607	+1.169	<.001	<.001	3	4
LIVER	ALDH3A2 →	-2.564	-1.475	.008	.005	2	5
CNS	MRPS34 →	-0.508	-0.866	.002	.008	3	4
STOMACH	GABARAPL1 →	+1.899	+1.028	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SATB1 by Negative regulation of microtubule polymerization activity — PANCREAS

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