Negative regulation of microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM7, POLR3K, and EPS8L1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of microtubule polymerization activity versus LSM7 in PANCREAS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LSM7 →	+0.868	+1.196	.003	.001	3	5
URINARY_TRACT	POLR3K →	+0.842	+1.141	.001	.008	3	5
BREAST	EPS8L1 →	-1.845	-0.785	.002	.002	3	5
LUNG_NSCLC_LUAD	MSLN →	-1.925	-0.528	.003	.008	3	4
LUNG_NSCLC_LUAD	MAD2L2 →	+0.546	+0.730	.007	.001	2	5
PANCREAS	YPEL5 →	-1.214	-1.166	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031115 vs LSM7 — PANCREAS

Explore this scatter interactively →