Microtubule polymerization or depolymerization

Across TCGA patient cohorts, RNA activity of the Microtubule polymerization or depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANLN, KIFC1, and SMC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization or depolymerization activity versus ANLN in LUAD (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ANLN →	+0.817	+0.049	<.001	<.001	3	8
LUAD	KIFC1 →	+0.580	+0.047	<.001	<.001	3	8
LUAD	SMC4 →	+0.521	+0.046	<.001	<.001	3	7
LUAD	DLGAP4_T915 →	+0.776	+0.041	<.001	<.001	3	7
LUAD	MAP1B_S614 →	+1.370	+0.033	<.001	<.001	3	7
LSCC	MAP1B_T1282 →	+1.018	+0.034	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031109 vs ANLN — LUAD

Explore this scatter interactively →