Microtubule polymerization or depolymerization

Across TCGA patient cohorts, RNA activity of the Microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS2, TAX1BP1, and AIMP2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization or depolymerization activity versus LGALS2 in COAD (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LGALS2 →	+2.130	+0.504	.003	<.001	3	1
COAD	TAX1BP1 →	+0.552	+0.373	.009	.003	3	1
COAD	AIMP2 →	+0.399	+0.442	<.001	<.001	3	1
COAD	ANKMY2 →	+0.453	+0.361	.002	.006	3	1
COAD	ARG1 →	+0.365	+0.372	.002	.002	3	1
COAD	TGFBI →	-1.337	-0.383	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031109 vs LGALS2 — COAD

Explore this scatter interactively →