Microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF6, IFT81, and PHF13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule polymerization or depolymerization activity versus TAF6 in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TAF6 →	+0.460	+0.144	.007	.004	3	5
BLOOD_Leukemia	IFT81 →	+0.728	+0.199	.006	.007	3	5
LARGE_INTESTINE	PHF13 →	+0.469	+0.421	.007	.008	3	4
LARGE_INTESTINE	CENPO →	+0.723	+0.632	.005	.004	3	4
LARGE_INTESTINE	AURKB →	+0.446	+0.418	.009	.009	2	5
BREAST	LMNB1 →	+0.703	+0.480	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031109 vs TAF6 — BLOOD_Lymphoma

Explore this scatter interactively →