Embryonic camera-type eye development

Across TCGA patient cohorts, RNA activity of the Embryonic camera-type eye development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN11, TLN2, and EFEMP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye development activity versus SEPTIN11 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SEPTIN11 →	+0.335	+0.058	.003	.003	3	7
LUAD	TLN2 →	+0.283	+0.040	.002	.004	3	6
PDAC	EFEMP1 →	+0.635	+0.040	<.001	<.001	3	6
OV	RAB23 →	+0.400	+0.069	.003	<.001	3	6
COAD	RO60 →	+0.278	+0.040	<.001	<.001	3	5
PDAC	SEPTIN2 →	+0.255	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031076 vs SEPTIN11 — OV

Explore this scatter interactively →