Embryonic camera-type eye development

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye development pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF91, ALDH1A3, and PPP2R3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye development activity versus ZNF91 in BONE (Pearson r = -0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ZNF91 →	-1.967	-2.125	.006	<.001	3	5
SOFT_TISSUE	ALDH1A3 →	+5.024	+1.600	.001	.005	1	6
SOFT_TISSUE	PPP2R3A →	+1.489	+1.600	.001	.005	3	4
SOFT_TISSUE	ARFRP1 →	+2.031	+2.039	<.001	<.001	3	3
SOFT_TISSUE	BMP2 →	+1.783	+2.039	<.001	<.001	3	3
BONE	TCTN2 →	+0.717	+2.125	.008	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031076 vs ZNF91 — BONE

Explore this scatter interactively →