Pre-miRNA processing

Across TCGA cell cohorts, RNA activity of the Pre-miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2R1, PAQR6, and LARS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2R1 grouped by Pre-miRNA processing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CYP2R1 →	-1.105	-0.940	.002	.003	3	6
BONE	PAQR6 →	-2.163	-1.624	.004	<.001	3	4
SOFT_TISSUE	LARS2 →	-1.142	-1.404	<.001	<.001	3	4
SOFT_TISSUE	MRPS25 →	-1.088	-1.627	.001	<.001	3	4
SOFT_TISSUE	ARID3B →	-1.424	-1.332	.009	.003	3	4
BONE	MKS1 →	-0.519	-1.153	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2R1 by Pre-miRNA processing activity — BREAST

Explore this box plot interactively →