Primary miRNA processing

Across TCGA patient cohorts, RNA activity of the Primary miRNA processing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, DPYSL3, and CACNA2D1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary miRNA processing activity versus FERMT2 in OV (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FERMT2 →	+0.452	+0.056	.001	<.001	3	7
BRCA	DPYSL3 →	+0.452	+0.027	<.001	<.001	3	7
OV	CACNA2D1 →	+0.547	+0.049	.001	<.001	3	6
BRCA	KANK2 →	+0.496	+0.054	<.001	<.001	3	6
BRCA	RPL27A →	-0.325	-0.033	<.001	<.001	3	6
BRCA	RPL5 →	-0.170	-0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031053 vs FERMT2 — OV

Explore this scatter interactively →