Primary miRNA processing

Across TCGA patient cohorts, RNA activity of the Primary miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, CRTAC1, and HNRNPCP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary miRNA processing activity versus MAP1A in GBM (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAP1A →	-0.829	-0.314	<.001	<.001	3	4
GBM	CRTAC1 →	-1.029	-0.255	<.001	<.001	3	4
HNSC	HNRNPCP2 →	+0.820	+0.267	.001	<.001	3	4
OV	ABCA8 →	-0.605	-0.130	.006	.007	2	4
OV	NTN4 →	-0.927	-0.194	<.001	<.001	3	3
COAD	MCM4 →	+0.453	+0.228	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031053 vs MAP1A — GBM

Explore this scatter interactively →