Primary miRNA processing

Across TCGA cell cohorts, RNA activity of the Primary miRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALG2, RCC2, and CDK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primary miRNA processing activity versus ALG2 in BLOOD_Myeloma (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ALG2 →	-1.508	-0.162	<.001	.009	3	5
CNS	RCC2 →	+0.588	+0.108	.001	.001	3	5
SKIN	CDK3 →	+0.469	+0.078	.001	.002	3	5
STOMACH	CCDC77 →	+1.265	+0.167	<.001	.009	3	4
STOMACH	TRIM28 →	+1.505	+0.153	.003	.005	3	4
STOMACH	PLEKHG4 →	+2.164	+0.141	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031053 vs ALG2 — BLOOD_Myeloma

Explore this scatter interactively →