Myosin filament organization

Across TCGA patient cohorts, RNA activity of the Myosin filament organization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO2_S155, FERMT2, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myosin filament organization activity versus SYNPO2_S155 in UCEC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SYNPO2_S155 →	+1.206	+0.096	<.001	<.001	3	8
UCEC	FERMT2 →	+0.697	+0.077	<.001	<.001	3	8
UCEC	RSU1 →	+0.449	+0.075	<.001	<.001	3	8
UCEC	TPM2 →	+1.227	+0.104	<.001	<.001	3	8
UCEC	PGM5 →	+0.877	+0.089	<.001	<.001	3	8
UCEC	MSRB3 →	+0.852	+0.094	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031033 vs SYNPO2_S155 — UCEC

Explore this scatter interactively →