Myosin filament organization

Across TCGA patient cohorts, RNA activity of the Myosin filament organization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNN1, FGF10, and LINC00702, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Myosin filament organization activity versus CNN1 in CCRCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNN1 →	+1.409	+0.876	<.001	<.001	3	5
BRCA	FGF10 →	+2.074	+0.535	<.001	<.001	3	5
LUAD	LINC00702 →	+0.255	+0.694	.008	.009	3	5
BRCA	ABCA8 →	+0.911	+0.307	.002	.008	2	5
CCRCC	ADH1B →	+1.314	+0.871	.001	.002	3	4
BRCA	ZBTB16 →	+1.077	+0.509	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031033 vs CNN1 — CCRCC

Explore this scatter interactively →