Endocrine pancreas development

Across TCGA cell cohorts, RNA activity of the Endocrine pancreas development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAL, BTBD3, and RPS26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAL grouped by Endocrine pancreas development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GAL →	-2.430	-0.634	<.001	.003	3	4
SOFT_TISSUE	BTBD3 →	-1.040	-0.793	.002	.005	3	4
LIVER	RPS26 →	-0.860	-0.380	.006	.001	3	3
OVARY	CFAP221 →	+0.809	+0.826	.008	.003	3	3
OVARY	SLC23A1 →	+0.573	+0.683	.007	.005	3	3
OVARY	C12orf60 →	-0.538	-0.701	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAL by Endocrine pancreas development activity — BREAST

Explore this box plot interactively →