Endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLDIP2, NIPSNAP2, and MSANTD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POLDIP2 grouped by Endoplasmic reticulum unfolded protein response-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	POLDIP2 →	-0.803	-0.346	.005	.007	3	5
LUNG_SCLC	NIPSNAP2 →	+0.956	+0.234	<.001	.001	3	5
BONE	MSANTD2 →	+1.146	+0.326	.009	<.001	2	5
BREAST	TMSB15B →	+1.855	+0.191	.002	.003	2	5
LUNG_NSCLC_LUSC	STK35 →	-0.744	-0.220	.006	.004	3	4
LUNG_NSCLC_LUSC	SSH2 →	-0.688	-0.218	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POLDIP2 by Endoplasmic reticulum unfolded protein response activity — BLOOD_Myeloma

Explore this box plot interactively →