Astral microtubule organization

Across TCGA patient cohorts, RNA activity of the Astral microtubule organization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELPLG, LST1, and RASGRP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astral microtubule organization activity versus SELPLG in LUAD (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SELPLG →	-0.588	-0.403	<.001	.001	3	4
BRCA	LST1 →	-0.572	-0.530	.001	.004	3	4
BRCA	RASGRP2 →	-0.580	-0.436	.001	.003	3	4
HNSC	TULP3 →	+0.457	+0.402	<.001	.004	3	4
LSCC	SBNO1 →	+0.468	+0.420	<.001	.009	3	4
LSCC	FGD2 →	-0.660	-0.457	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030953 vs SELPLG — LUAD

Explore this scatter interactively →