Astral microtubule organization

Across TCGA cell cohorts, RNA activity of the Astral microtubule organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF4A1, PCDH1, and TSPAN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astral microtubule organization activity versus EIF4A1 in PANCREAS (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	EIF4A1 →	-0.927	-0.451	<.001	<.001	3	6
OESOPHAGUS	PCDH1 →	+2.625	+0.296	<.001	<.001	3	6
OESOPHAGUS	TSPAN1 →	+3.095	+0.340	<.001	<.001	3	5
BREAST	YARS1 →	-0.716	-0.240	.008	.009	3	5
BREAST	SSRP1 →	-0.628	-0.196	.006	.006	3	5
BREAST	S100A14 →	+3.817	+0.225	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030953 vs EIF4A1 — PANCREAS

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