Establishment or maintenance of cytoskeleton polarity

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTDSPL, APBA1, and BCL7C, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of cytoskeleton polarity activity versus CTDSPL in LSCC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CTDSPL →	+0.321	+0.151	<.001	.001	3	6
LUAD	APBA1 →	+0.538	+0.298	<.001	.001	3	5
LUAD	BCL7C →	+0.235	+0.251	.001	.003	3	5
HNSC	CAMSAP3 →	+0.937	+0.621	<.001	<.001	3	5
CCRCC	HABP4 →	+0.680	+0.850	<.001	<.001	3	5
OV	GINS1 →	-0.508	-0.129	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030952 vs CTDSPL — LSCC

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