Establishment or maintenance of cytoskeleton polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUSC3, DDX28, and CCM2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUSC3 grouped by Establishment or maintenance of cytoskeleton polarity-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TUSC3 →	+2.472	+0.144	.005	.004	3	5
LUNG_NSCLC_LUAD	DDX28 →	-0.524	-0.163	<.001	<.001	3	4
SOFT_TISSUE	CCM2 →	+1.004	+0.202	<.001	.001	2	5
LUNG_NSCLC_LUAD	CDH24 →	+0.766	+0.102	<.001	.001	3	4
BLOOD_Lymphoma	ENY2 →	-0.803	-0.206	.001	.003	3	4
LARGE_INTESTINE	DECR1 →	-0.996	-0.223	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUSC3 by Establishment or maintenance of cytoskeleton polarity activity — OESOPHAGUS

Explore this box plot interactively →