Establishment or maintenance of cytoskeleton polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TYK2, SNAI1, and POLR2E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TYK2 grouped by Establishment or maintenance of cytoskeleton polarity-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TYK2 →	-0.161	-0.174	<.001	<.001	3	5
URINARY_TRACT	SNAI1 →	+0.226	+0.432	.008	.008	3	4
BLOOD_Lymphoma	POLR2E →	+0.603	+0.361	.002	.006	3	4
LUNG_SCLC	MTHFD2L →	+0.187	+0.248	<.001	.003	3	4
BREAST	POLR2L →	+0.384	+0.180	<.001	.003	3	4
STOMACH	COQ5 →	-0.234	-0.236	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TYK2 by Establishment or maintenance of cytoskeleton polarity activity — BREAST

Explore this box plot interactively →