Establishment or maintenance of cytoskeleton polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cytoskeleton polarity pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDLIM1, BAD, and GBP3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of cytoskeleton polarity activity versus PDLIM1 in CNS (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PDLIM1 →	+3.041	+0.214	<.001	<.001	3	10
OESOPHAGUS	BAD →	+1.298	+0.240	<.001	<.001	3	5
STOMACH	GBP3 →	+2.753	+0.255	.004	<.001	3	5
BREAST	AJUBA →	+1.327	+0.191	.001	<.001	3	5
BREAST	EHD2 →	+2.969	+0.181	.003	.007	3	5
BLOOD_Leukemia	MAPKAPK3 →	-0.811	-0.524	.008	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030952 vs PDLIM1 — CNS

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