Paranodal junction assembly

Across TCGA cell cohorts, RNA activity of the Paranodal junction assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1A1, INCENP, and OPN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSNK1A1 grouped by Paranodal junction assembly-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSNK1A1 →	+0.290	+0.232	.003	.002	3	6
URINARY_TRACT	INCENP →	+0.381	+0.362	<.001	<.001	3	4
BREAST	OPN3 →	-0.158	-0.205	.003	.008	3	4
LUNG_NSCLC_LUAD	DKK3 →	-0.145	-0.211	.006	.004	3	4
LUNG_NSCLC_LUAD	LOXL3 →	-0.118	-0.149	.007	.004	3	4
BLOOD_Leukemia	TUBB →	-0.364	-1.016	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSNK1A1 by Paranodal junction assembly activity — LARGE_INTESTINE

Explore this box plot interactively →