Paranodal junction assembly

Across TCGA cell cohorts, RNA activity of the Paranodal junction assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPUL1, NELFCD, and PIAS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Paranodal junction assembly activity versus HNRNPUL1 in URINARY_TRACT (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HNRNPUL1 →	-0.843	-1.794	.007	<.001	3	3
LUNG_SCLC	NELFCD →	-0.734	-1.276	<.001	<.001	3	3
OESOPHAGUS	PIAS1 →	-0.899	-1.675	.005	.002	3	3
STOMACH	ZDHHC9 →	-1.170	-1.666	<.001	<.001	3	3
OESOPHAGUS	RALGPS2 →	-1.731	-1.476	<.001	<.001	3	3
OESOPHAGUS	ATP5F1E →	-1.014	-1.395	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030913 vs HNRNPUL1 — URINARY_TRACT

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