Notochord development

Across TCGA patient cohorts, RNA activity of the Notochord development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDKN1B, MMP14, and CDKN1B_S178, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Notochord development activity versus CDKN1B in BRCA (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CDKN1B →	-0.487	-0.064	<.001	<.001	3	6
LUAD	MMP14 →	+0.434	+0.048	<.001	.005	3	6
BRCA	CDKN1B_S178 →	-0.998	-0.066	<.001	.006	3	5
HNSC	SMC4 →	+0.358	+0.090	.001	<.001	3	5
LUAD	FOSL2_S120 →	+0.589	+0.060	.001	.004	3	5
LSCC	ISOC1 →	-0.312	-0.070	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030903 vs CDKN1B — BRCA

Explore this scatter interactively →