Hindbrain development

Across TCGA cell cohorts, RNA activity of the Hindbrain development pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPP3, RNF123, and CSTF2T, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPP3 grouped by Hindbrain development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DPP3 →	-0.165	-0.059	.001	.001	3	4
LIVER	RNF123 →	+0.273	+0.072	<.001	.003	3	4
BONE	CSTF2T →	+0.201	+0.081	<.001	<.001	3	4
STOMACH	FAM98C →	-0.314	-0.182	.001	<.001	3	4
STOMACH	RPIA →	-0.167	-0.124	.002	<.001	3	4
SKIN	NRP1 →	+0.253	+0.049	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPP3 by Hindbrain development activity — KIDNEY

Explore this box plot interactively →