Hindbrain development

Across TCGA cell cohorts, RNA activity of the Hindbrain development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERO1A, C10orf143, and KDM4D, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hindbrain development activity versus ERO1A in BLOOD_Lymphoma (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ERO1A →	+1.173	+0.202	.005	.003	3	5
BONE	C10orf143 →	-0.927	-0.293	.001	.004	2	6
SOFT_TISSUE	KDM4D →	-0.403	-0.169	.001	<.001	3	4
LUNG_SCLC	SLC16A10 →	-1.080	-0.171	<.001	.008	3	4
LUNG_SCLC	PDXP →	-0.857	-0.250	.003	.001	3	4
LIVER	RABEPK →	-0.654	-0.238	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030902 vs ERO1A — BLOOD_Lymphoma

Explore this scatter interactively →