Positive regulation of B cell proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLINT1, LATS2, and HMGA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of B cell proliferation activity versus CLINT1 in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CLINT1 →	+1.395	+0.370	<.001	<.001	3	4
STOMACH	LATS2 →	+1.589	+0.404	.005	.001	3	4
LUNG_NSCLC_LUAD	HMGA1 →	-1.402	-0.144	<.001	.005	3	4
LIVER	SLC25A34 →	+0.408	+0.271	<.001	.001	3	4
SKIN	CXADR →	+1.198	+0.227	<.001	<.001	3	4
BLOOD_Lymphoma	PACSIN3 →	-1.290	-0.236	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030890 vs CLINT1 — STOMACH

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