Negative regulation of B cell proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of B cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRPG, TRG-AS1, and IL2RA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of B cell proliferation activity versus SIRPG in UCEC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SIRPG →	+0.991	+0.686	<.001	<.001	3	9
UCEC	TRG-AS1 →	+0.618	+0.733	<.001	<.001	3	9
GBM	IL2RA →	+0.897	+0.415	<.001	<.001	3	8
OV	CD72 →	+0.851	+0.780	<.001	<.001	3	8
OV	LY96 →	+1.151	+0.833	<.001	<.001	3	8
OV	SLA →	+0.880	+0.704	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030889 vs SIRPG — UCEC

Explore this scatter interactively →