Mammary gland development

Across TCGA patient cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IGFBP7, RCN3, and SEPTIN11, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland development activity versus IGFBP7 in PDAC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	IGFBP7 →	+0.485	+0.024	.004	.001	3	6
BRCA	RCN3 →	+0.335	+0.022	.009	.002	3	5
BRCA	SEPTIN11 →	+0.317	+0.021	<.001	<.001	3	5
BRCA	SEPTIN7 →	+0.287	+0.030	<.001	<.001	3	5
BRCA	SERPINF1 →	+0.724	+0.030	<.001	<.001	3	5
BRCA	SETD7 →	+0.336	+0.033	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030879 vs IGFBP7 — PDAC

Explore this scatter interactively →