Mammary gland development

Across TCGA pan-cancer cohorts, RNA activity of the Mammary gland development pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 133 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Mammary gland development pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and HNSC, show the opposite pattern, with higher activity associated with better survival.

KIRP, MESO, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.570	0.757	<.001	102	view →
MESO	OS	Median	All	0.260	0.462	.001	75	view →
LGG	DFS	Median	All	0.672	0.803	<.001	47	view →
BRCA	OS	Tertile	All	0.962	0.909	.003	44	view →
HNSC	DFS	Quartile	IV	0.580	0.326	.003	43	view →
UVM	OS	Median	All	0.718	0.468	.003	41	view →
OV	OS	Tertile	All	0.752	0.873	.006	40	view →
READ	OS	Median	II,III,IV	0.868	0.413	<.001	33	view →
STAD	OS	Quartile	All	0.325	0.674	.020	18	view →
SCLC	OS	Median	III,IV	0.626	0.303	.010	17	view →
ESCA	OS	Median	III,IV	0.603	0.318	.003	12	view →
KIRC	DFS	Tertile	III,IV	0.289	0.547	.012	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0030879–KIRP (OS)

Open the KIRP breakdown →