Mammary gland development

Across TCGA patient cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBKB, LINC02080, and RNF170, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland development activity versus IKBKB in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IKBKB →	+0.482	+0.727	.009	.001	3	3
BRCA	LINC02080 →	+0.192	+0.906	.001	.009	3	3
OV	RNF170 →	+0.560	+1.000	.001	.001	3	3
PDAC	CXCR4 →	-0.940	-1.442	<.001	<.001	3	3
CCRCC	ITPKA →	+0.635	+0.341	.006	.006	3	2
BRCA	UTP4 →	-0.493	-0.952	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030879 vs IKBKB — BRCA

Explore this scatter interactively →