Mammary gland development

Across TCGA patient cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IRS2, IRS2_S560, and GTSE1_S262, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland development activity versus IRS2 in CCRCC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	IRS2 →	+0.469	+0.422	<.001	<.001	3	2
OV	IRS2_S560 →	+0.705	+1.080	<.001	<.001	2	3
BRCA	GTSE1_S262 →	-1.158	-1.396	.004	.003	3	2
BRCA	MRE11_S558 →	+0.870	+1.606	<.001	<.001	3	2
OV	OBI1_S719 →	-0.968	-1.156	<.001	<.001	3	2
OV	BRMS1_S237 →	-1.358	-1.035	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030879 vs IRS2 — CCRCC

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