Mammary gland development

Across TCGA cell cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEA15, GSTA4, and LRRC8C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEA15 grouped by Mammary gland development-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PEA15 →	-1.390	-0.759	<.001	.003	3	3
OVARY	GSTA4 →	+1.608	+0.571	<.001	.003	3	3
PANCREAS	LRRC8C →	-1.396	-0.253	.003	.004	3	3
KIDNEY	SLC16A13 →	+0.998	+0.899	<.001	.001	3	3
PANCREAS	AK2 →	-0.832	-0.257	.002	.001	3	3
PANCREAS	SYNJ2 →	-1.242	-0.321	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEA15 by Mammary gland development activity — OVARY

Explore this box plot interactively →