Mammary gland development

Across TCGA cell cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUZ12, KCP, and NIBAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUZ12 grouped by Mammary gland development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SUZ12 →	+0.201	+0.160	.001	<.001	3	5
OVARY	KCP →	+0.248	+0.087	.007	<.001	3	5
LUNG_NSCLC_LUAD	NIBAN2 →	+0.267	+0.112	.002	<.001	3	4
LUNG_NSCLC_LUAD	SAE1 →	+0.110	+0.059	<.001	.002	3	4
LUNG_NSCLC_LUAD	NYAP1 →	+0.145	+0.070	<.001	.005	3	4
STOMACH	PSMA8 →	-0.228	-0.129	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUZ12 by Mammary gland development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →