Mammary gland development

Across TCGA cell cohorts, RNA activity of the Mammary gland development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC39A, BICDL1, and DHRS13, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland development activity versus TTC39A in BREAST (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TTC39A →	-4.115	-0.287	<.001	<.001	3	6
KIDNEY	BICDL1 →	-2.087	-0.300	.003	.004	3	6
SOFT_TISSUE	DHRS13 →	-1.206	-0.407	.001	.002	3	6
SOFT_TISSUE	AXL →	+3.953	+0.555	.001	<.001	3	6
LUNG_NSCLC_LUAD	SERPINE1 →	+2.889	+0.183	.001	.002	3	6
BREAST	IGFBP6 →	+3.313	+0.375	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030879 vs TTC39A — BREAST

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