Cortical actin cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Cortical actin cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IQCA1, GLT8D2, and PMP22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortical actin cytoskeleton organization activity versus IQCA1 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IQCA1 →	+1.834	+0.298	<.001	.001	3	5
BRCA	GLT8D2 →	+0.962	+0.207	.002	.001	3	5
OV	PMP22 →	+0.796	+0.177	.004	.002	3	5
BRCA	GPC6 →	+0.941	+0.217	.001	.002	3	5
BRCA	PRKG1 →	+0.528	+0.171	.006	.008	3	5
PDAC	CHSY3 →	+0.482	+0.201	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030866 vs IQCA1 — UCEC

Explore this scatter interactively →