Cortical actin cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Cortical actin cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB22, CBR4, and CTNNAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBTB22 grouped by Cortical actin cytoskeleton organization-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZBTB22 →	-0.744	-0.249	.004	.009	2	4
KIDNEY	CBR4 →	-0.918	-1.520	<.001	<.001	3	3
LUNG_SCLC	CTNNAL1 →	-0.906	-0.544	.005	.004	3	3
LARGE_INTESTINE	NMRK1 →	+1.100	+0.871	.002	.003	3	3
URINARY_TRACT	CORO1C →	+1.540	+0.199	.005	.008	2	3
LUNG_NSCLC_LUAD	RCN2 →	+0.521	+0.610	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBTB22 by Cortical actin cytoskeleton organization activity — BLOOD_Myeloma

Explore this box plot interactively →