Cortical actin cytoskeleton organization

Across TCGA cell cohorts, RNA activity of the Cortical actin cytoskeleton organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MGST2, NAT1, and LGALS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortical actin cytoskeleton organization activity versus MGST2 in BLOOD_Myeloma (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MGST2 →	+3.051	+0.223	.001	.003	3	6
LUNG_SCLC	NAT1 →	+1.153	+0.206	.002	.001	3	6
BLOOD_Leukemia	LGALS1 →	+2.974	+0.192	.002	.004	3	5
CNS	SRSF12 →	-0.841	-0.226	.007	.004	3	5
BLOOD_Lymphoma	SHB →	+2.077	+0.228	.004	.006	3	5
STOMACH	PCSK1N →	-3.395	-0.405	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030866 vs MGST2 — BLOOD_Myeloma

Explore this scatter interactively →