Cortical cytoskeleton organization

Across TCGA patient cohorts, RNA activity of the Cortical cytoskeleton organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EPB41L3, RENBP, and LCP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cortical cytoskeleton organization activity versus EPB41L3 in OV (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EPB41L3 →	+0.579	+0.061	.001	.001	3	9
UCEC	RENBP →	+0.483	+0.072	<.001	<.001	3	8
LUAD	LCP2 →	+0.426	+0.055	<.001	<.001	3	8
COAD	PLEKHO2 →	+0.422	+0.038	.001	<.001	3	8
LSCC	ARHGAP45 →	+0.330	+0.052	.008	<.001	3	8
OV	STAB1 →	+0.348	+0.065	.004	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030865 vs EPB41L3 — OV

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